For this reason, hormones are critically important in human development and tissue repair. The most important message they deliver is to grow, divide, and multiply. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues.). Hormones have important functions in every area of the body. These compounds have generally been thought to be responsible for the various cellular activities that lead to hormone health.Įstrogen collectively refers to the female hormones estradiol, estrone and estriol. I3C can then be further converted via stomach acid into other health promoting compounds, including DIM. For instance, glucosinolates from broccoli and brussel sprouts readily convert into I3C when consumed. When these vegetables are cut, crushed or chewed, the actions of the enzyme myrosinase (released from the cells) hydrolyses these glucosinolates into other compounds. Many of the health benefits derived from eating cruciferous vegetables (cabbage, brussels sprouts, broccoli, etc.), especially those shown to be beneficial for breast and prostate health, are thought to be derived from the group of secondary metabolites known as glucosinolates. The Health Benefits of Cruciferous Vegetable Metabolites Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance, breast and prostate health. The review described current evidence related to the metabolism and mechanisms of DIM involved in the prevention of breast cancer.ĮstroDIM is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism. Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. Research of the cancer-preventive activity of DIM has revealed basic mechanistic, animal, and human trial data. A recent study focused on 3,3′-diindolylmethane (DIM), the major bioactive indole in crucifers. The role of cruciferous vegetables, is an active area of research in cancer chemoprevention. Diet is a modifiable factor associated with the risk of several cancers, with convincing evidence showing a link between diet and breast cancer.
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